pI: 8.357 |
Length (AA): 496 |
MW (Da): 57057 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 57 | 4kmf (A) | 5 | 60 | 27.00 | 0.14 | 0.98 | 0.638203 | -1.79 |
3 | 495 | 3l4g (C) | 5 | 494 | 46.00 | 0 | 1 | 1.43485 | 0.37 |
3 | 60 | 1r22 (A) | 46 | 106 | 23.00 | 0.88 | 0.8 | 0.491235 | -0.96 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127036)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G39280 | probable phenylalanine--tRNA ligase alpha subunit |
Babesia bovis | BBOV_III007240 | phenylalanyl-tRNA synthetase family protein |
Brugia malayi | Bm1_08535 | phenylalanyl (f) trna synthetase protein 1 |
Candida albicans | CaO19.10477 | phenylalanyl-tRNA synthetase |
Candida albicans | CaO19.2960 | phenylalanyl-tRNA synthetase |
Caenorhabditis elegans | CELE_T08B2.9 | Protein FARS-1, isoform A |
Cryptosporidium hominis | Chro.30378 | phenylalanyl-trna synthetase-like protein |
Cryptosporidium parvum | cgd3_3320 | putative phenylalanyl-tRNA synthetase |
Chlamydia trachomatis | CT_836 | phenylalanine--tRNA ligase subunit alpha |
Dictyostelium discoideum | DDB_G0287141 | phenylalanine-tRNA ligase, alpha subunit |
Drosophila melanogaster | Dmel_CG2263 | CG2263 gene product from transcript CG2263-RA |
Escherichia coli | b1714 | phenylalanine tRNA synthetase, alpha subunit |
Echinococcus granulosus | EgrG_001147900 | phenylalanyl tRNA synthetase alpha chain B |
Entamoeba histolytica | EHI_078230 | phenylalanyl-tRNA synthetase alpha subunit, putative |
Echinococcus multilocularis | EmuJ_001147900 | phenylalanyl tRNA synthetase alpha chain B |
Giardia lamblia | GL50803_12162 | Phenylalanyl-tRNA synthetase alpha chain |
Homo sapiens | ENSG00000179115 | phenylalanyl-tRNA synthetase, alpha subunit |
Leishmania braziliensis | LbrM.32.0960 | phenylalanyl-tRNA synthetase alpha chain, putative |
Leishmania donovani | LdBPK_320920.1 | phenylalanyl-tRNA synthetase alpha chain, putative |
Leishmania infantum | LinJ.32.0920 | phenylalanyl-tRNA synthetase alpha chain, putative |
Leishmania major | LmjF.32.0870 | phenylalanyl-tRNA synthetase alpha chain, putative |
Leishmania mexicana | LmxM.31.0870 | phenylalanyl-tRNA synthetase alpha chain, putative |
Loa Loa (eye worm) | LOAG_01536 | hypothetical protein |
Mycobacterium leprae | ML1401 | Probable phenylalanyl-tRNA synthetase, alpha chain PheS |
Mus musculus | ENSMUSG00000003808 | phenylalanyl-tRNA synthetase, alpha subunit |
Mycobacterium tuberculosis | Rv1649 | Probable phenylalanyl-tRNA synthetase, alpha chain PheS |
Mycobacterium ulcerans | MUL_1635 | phenylalanyl-tRNA synthetase subunit alpha |
Neospora caninum | NCLIV_042270 | hypothetical protein |
Oryza sativa | 4348566 | Os10g0400800 |
Plasmodium berghei | PBANKA_0203800 | phenylalanine--tRNA ligase alpha subunit, putative |
Plasmodium falciparum | PF3D7_0109800 | phenylalanine--tRNA ligase alpha subunit |
Plasmodium knowlesi | PKNH_0204000 | phenylalanine--tRNA ligase alpha subunit, putative |
Plasmodium vivax | PVX_081300 | phenylalanine--tRNA ligase alpha subunit, putative |
Plasmodium yoelii | PY00417 | phenylalanyl-tRNA synthetase, putative |
Saccharomyces cerevisiae | YFL022C | phenylalanine--tRNA ligase subunit alpha |
Schistosoma japonicum | Sjp_0080790 | ko:K01889 phenylalanyl-tRNA synthetase alpha chain [EC6.1.1.20A], putative |
Schistosoma mansoni | Smp_101240 | phenylalanyl-tRNA synthetase subunit alpha |
Schmidtea mediterranea | mk4.039025.03 | |
Trypanosoma brucei gambiense | Tbg972.11.15780 | phenylalanyl-tRNA synthetase alpha chain, putative |
Trypanosoma brucei | Tb927.11.14120 | phenylalanyl-tRNA synthetase alpha chain, putative |
Trypanosoma congolense | TcIL3000.11.14420 | phenylalanyl-tRNA synthetase alpha chain, putative |
Trypanosoma cruzi | TcCLB.511727.140 | phenylalanyl-tRNA synthetase alpha chain, putative |
Toxoplasma gondii | TGME49_234505 | phenylalanyl-tRNA synthetase alpha chain A, putative |
Treponema pallidum | TP0973 | phenylalanyl-tRNA synthetase subunit alpha |
Theileria parva | TP04_0622 | phenylalanyl-tRNA synthetase alpha chain, putative |
Trichomonas vaginalis | TVAG_136640 | phenylalanyl-tRNA synthetase alpha chain, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0087 | phenylalanyl-tRNA synthetase subunit alpha |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1678 | Mycobacterium tuberculosis | essential | nmpdr |
Tb11.01.5710 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.5710 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.5710 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.5710 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1714 | Escherichia coli | essential | goodall |
CELE_T08B2.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T08B2.9 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T08B2.9 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T08B2.9 | Caenorhabditis elegans | sterile | wormbase |
CELE_T08B2.9 | Caenorhabditis elegans | terminal arrest variable | wormbase |
YFL022C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0203800 | Plasmodium berghei | Essential | plasmo |
TGME49_234505 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Staphylococcus aureus | Phenylalanyl-tRNA synthetase alpha chain | Compounds | References |
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | Phenylalanyl-tRNA synthetase alpha chain | Compounds | References |
Streptococcus pyogenes serotype M18 (strain MGAS8232) | Phenylalanyl-tRNA synthetase alpha chain | Compounds | References |
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) | Phenylalanyl-tRNA synthetase alpha chain | Compounds | References |
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) | Type-2 restriction enzyme HindIII | Compounds | References |
1 literature reference was collected for this gene.